The use of a synthetic prostaglandin E1 analog as a gastric protectant against aspirin-induced hemorrhage in the dog

Misoprostol prevented gastric hemorrhage in dogs, each of which received aspirin (35 mg/kg body weight, orally q 8 hrs for 10 days). All dogs receiving aspirin alone had gastroscopic and histopathological lesions. No lesions were noted in four of five dogs given aspirin plus misoprostol (15 micrograms/kg body weight, q 8 hrs for five days; then 7.5 micrograms/kg body weight, q 8 hrs for five days). Four of 10 dogs receiving 15 micrograms/kg body weight of misoprostol developed diarrhea. The misoprostol dose was reduced to 7.5 micrograms/kg body weight, and the diarrhea subsided.